MPS

MPS & Related Diseases

Mucopolysaccharidoses (MPS) and related diseases are genetic lysosomal storage diseases (LSD) caused by the body’s inability to produce specific enzymes. Normally, the body uses enzymes to break down and recycle materials in cells. In individuals with MPS and related diseases, the missing or insufficient enzyme prevents the proper recycling process, resulting in the storage of materials in virtually every cell of the body. As a result, cells do not perform properly and may cause progressive damage throughout the body, including the heart, bones, joints, respiratory system and central nervous system. While the disease may not be apparent at birth, signs and symptoms develop with age as more cells become damaged by the accumulation of cell materials.

In a continuing effort to provide support and information to individuals about mucopolysaccharidoses and related diseases, the National MPS Society has created a central location for more information on MPS. Click here to go to the MPS Library.

MPS Diseases

The National MPS Society provides support to families and promotes research initiatives that affect the following diseases:

MPS I

  • Hurler Syndrome
  • Scheie Syndrome
  • Hurler-Scheie Syndrome

MPS II

  • Hunter Syndrome

MPS III

  • Sanfilippo A
  • Sanfilippo B
  • Sanfilippo C
  • Sanfilippo D

MPS IV

  • Morquio A
  • Morquio B
MPS V

  • Formerly Scheie Syndrome

MPS VI

  • Maroteaux-Lamy

MPS VII

  • Sly Syndrome

ML II/III

  • I-cell
  • Pseudo-Hurler polydystrophy