Mucopolysaccharidoses (MPS) and mucolipidosis (ML) are rare genetic lysosomal storage diseases caused by the body’s inability to produce certain enzymes. Without these enzymes, cells cannot properly break down and recycle waste, leading to the buildup of harmful materials throughout the body. Over time, this buildup causes progressive damage to the heart, bones, joints, respiratory system, and central nervous system—ultimately shortening lifespan.